Applications: Control of phytophagous mites (particularly motile stages) on a variety of crops, including vines, fruit trees (e.g. top fruit, stone fruit, citrus fruit), hops, nuts, tomatoes, vegetables, ornamentals, cotton, maize, peanuts, and sorghum. Used at rates from 0.75-1.8 kg/ha on row crops and foliar sprays of 0.85-3.0 kg/ha on perennial fruit and nut crops. Toxicology: Reviews FAO/WHO 86, 88 (see part 2 of the Bibliography). Oral Acute oral LD50 for rats 2800 mg/kg. Skin and eye Acute percutaneous LD50 for rabbits 4000 mg/kg. Severe eye and skin irritant to rabbits. Not a skin sensitiser to guinea pigs. Inhalation LC50 (4 h) for rats 0.05 mg/l. NOEL NOEL (1 y) for dogs 4 mg/kg b.w. daily; LOAEL (2 y) for SD rats 3 mg/kg b.w. daily, based on occurrence of jejunal tumours. Tumours not seen in Wistar rats or mice. NOAEL for SD rats (28 d) is 2 mg/kg b.w., indicating that cell proliferation is the cause of carcinogenicity and that there is a threshold dose; therefore, carcinogenicity is species and strain specific. ADI(JMPR) 0.01 mg/kg b.w. [1999]. Other Not genotoxic. Acute i.p. LC50 for male rats 260, female rats 172 mg/kg.Toxicity class WHO (a.i.) III (tech.); EPA (formulation) III EC classification Xn; R22| Xi; R36| N; R50, R53: (draft 29th ATP proposes R40| T; R23| Xi; R38, R41| N; R50, R53, concentration dependent)